Paraguay and the United States have widespread relations at the business, personal and government level.

Paraguay is an associate in hemispheric projects to enhance combat money laundering, counter narcotics cooperation, human trafficking, and other illegal cross-border movements, and tolerably shield intellectual property rights. The US looks to Paraguay, which has riverine resources and tropical forest, to connect in hemispheric efforts to make sure sustainable progress. Paraguay and the US also oblige in a plenty of international organizations.

Paraguay has taken considerable steps to combat terrorism-financing movement in the tri-border region it shares with Brazil and Argentina. It takes part in anti terrorism movements and fora, counting the "Three plus One Security Dialogue", with the United States and adjoins nations.

The US stoutly backs consolidation of Paraguay's democratic system and sustained economic restructuring, the keystones of assistance amongst nations in the hemisphere. The US has played significant roles in shielding Paraguay's independent institutions, in assisting resolve the April 1996 catastrophe, and in making sure that, the March 1999 change of government took place with no extra bloodshed.

Mutual trade with the US has improved over the past 4 years, after a stable decline over quite a few years because of an enduring downturn of the Paraguayan financial system. However, the United States imports from Paraguay had been only $51.28mn in year 2005, down from $58.58mn the past year, United States exports to Paraguay in year 2005 were $895.53mn up from $622.87mn in year 2004, based on the United States Customs data. More than 12 United States MNC’s have subsidiaries in Paraguay. These comprise companies in the agro-industrial, computer, banking, telecom, and other service industries. Some seventy-five businesses have representatives or agents in Paraguay, and more than three thousand United States citizens live in the nation.